Optimizing the Appropriate Use of Pharmacologic Stress Agents in
Cardiovascular Imaging Based on Patient Profiles Web Activity

Target Audience

This activity has been designed to meet the educational needs of clinicians involved in or with an interest in utilizing single-photon emission computed tomography myocardial perfusion imaging (SPECT MPI or MPI).

Statement of Need/Program Overview

In order to accurately diagnose and/or characterize CAD in patients via SPECT MPI, clinicians must have extensive expertise in performing and interpreting the test. This includes knowledge of testing protocols, as well as selection of the appropriate pharmacologic stress agent for individual patients. Considering the recent developments in cardio medical imaging, including the approval of a new pharmacologic stress agent in 2008, educational intervention is necessary to keep cardiologists and associated clinicians current. Furthermore, an unmet educational need has been identified regarding cardiologists' awareness of appropriate selection of available pharmacological stress agents for different patient profiles.

Educational Objectives
After completing this activity, the participant should be better able to:


Distinguished Faculty
Manuel D. Cerqueira, MD, FACC, FASNC, FAHA
Chairman of Nuclear Medicine, Imaging Institute
Staff Cardiologist, Sydell and Arnold Miller Family
         Heart & Vascular Institute Cleveland Clinic Foundation
Professor of Radiology and Medicine,
         Cleveland Clinic Lerner College of Medicine,
         Case Western Reserve University

Click here for biography
John J. Mahmarian, MD, FACC, FASNC, FSCCT
Professor of Medicine, Weill Cornell Medical College
Director of the Nuclear Cardiology and CT Laboratories,
         Methodist DeBakey Heart and Vascular Center,
         The Methodist Hospital

Click here for biography

Activity Agenda

Physician Continuing Medical Education

Accreditation Statement:
This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of Postgraduate Institute for Medicine (PIM) and Impact Education, LLC. PIM is accredited by the ACCME to provide continuing medical education for physicians.

Credit Designation:
Postgraduate Institute for Medicine designates this educational activity for a maximum of 2.5 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Fee Information

There is no fee for this educational activity.

Disclosure of Conflicts of Interest

Postgraduate Institute for Medicine (PIM) assesses conflict of interest with its instructors, planners, managers and other individuals who are in a position to control the content of CME activities. All relevant conflicts of interest that are identified are thoroughly vetted by PIM for fair balance, scientific objectivity of studies utilized in this activity, and patient care recommendations. PIM is committed to providing its learners with high quality CME activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of a commercial interest.

The faculty reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME activity:

Name of Faculty or Presenter

Reported Financial Relationship

Manuel D. Cerqueira

Consulting Fees: Astellas, GE Healthcare, Lantheus Medical Imaging, CoreLab Partners
Fees for Non-CME/CE Services Received Directly From a Commercial Interest or Their Agents: Astellas, GE Healthcare
Contracted Research: Perceptive Informatics

John J. Mahmarian

Consulting Fees: Astellas
Fees for Non-CME/CE Services Received Directly From a Commercial Interest or Their Agents: Astellas

The planners and managers reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME activity:

Name of Planner

Reported Financial Relationship

Steve Casebeer, MBA
(Impact Education, LLC)

No financial interest/relationships relating to the topic of this activity

The following PIM planners and managers, Jan Hixon, RN, BSN, MA, Patricia Staples, MSN, NP-C, CCRN, Trace Hutchison, PharmD, Julia Kimball, RN, BSN, Samantha Mattiucci, PharmD and Jan Schultz, RN, MSN, CCMEP hereby state that they or their spouse/life partner do not have any financial relationships or relationships to products or devices with any commercial interest related to the content of this activity of any amount during the past 12 months.

Method of Participation and Request for Credit

There are no fees for participating and receiving CME/CE credit for this activity. During the period December 30, 2010 through June 30, 2012, participants must 1) read the learning objectives and faculty disclosures; 2) study the educational activity; 3) successfully complete the online post-test, with a passing score of 70% or better; 4) complete the online evaluation form. Upon successful completion of post-test and evaluation, you will have access to an immediate online certificate.



Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Postgraduate Institute for Medicine (PIM), Impact Education, LLC, and Astellas Pharma US, LLC, do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of PIM, Impact Education, LLC, and Astellas Pharma US, LLC. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient's conditions and possible contraindications on dangers in use, review of any applicable manufacturer's product information, and comparison with recommendations of other authorities.